Accutane (isotretinoin) is a powerful medication that is approved for people with severe acne that is non-responsive to other treatments. It is the most effective medication on the market for acne, but also comes with a worrying list of side effects, some of which can be lifelong. Jan 19, · Accutane is extremely effective at treating acne. But, it also comes with many side effects. Some common side effects of Accutane may subside after initial treatment.. Dry skin, lips and eyes are common in some patients taking 7458.info: Kristin Compton. Accutane (isotretinoin) is a retinoid used for the treatment and prevention of severe 7458.info brand name Accutane is discontinued in the U.S., but generic formulations are available The most common side effects of Accutane are. dry skin,; itching, ; rash, ; dry nose, nosebleeds, cracks in .