Because of Accutane (isotretinoin) 's teratogenicity and to minimize fetal exposure, Accutane (isotretinoin) is approved for marketing only under a special restricted distribution program approved by the Food and Drug Administration. 20 major drug interactions (87 brand and generic names) 99 moderate drug interactions ( brand and generic names) Show all medications in the database that may interact with Accutane (isotretinoin). Isotretinoin (Claravis, Amnesteem, Absorica, Myorisan, Zenatane, Sotret) a a prescription drug used to treat severe acne. The brand name Accutane is no longer available. Side effects include nosebleeds, dry mouth, joint aches, dry skin, and itching. Dosage, drug interactions, and pregnancy and breastfeeding safety should be reviewed prior to using this medication.